Others have suggested that there are combinations of factors that influence the etiology of ASD, including the interaction of genes with environmental factors. A number of studies have indicated that ASD has a heritable factor. Currently, the etiology of ASD is not well understood. Our findings also indicate that BMC in Jamaican children resemble those of children in the developed world and are much lower than those in the developing countries.Īutism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impairs social interaction and communication. While these results cannot be used to assess early exposure at potentially more susceptible time period, our findings suggest that there is no significant association between manganese exposures and ASD case status in Jamaica. Our findings also indicated TD children who ate fresh water fish had a higher BMC than children who did not (11.0 μg/L vs. In a multivariable GLM adjusting for paternal age, parental education, place of child’s birth (Kingston parish), consumption of root vegetables, cabbage, saltwater fish, and cakes/buns, there was still no significant association between BMC and ASD status, (11.5 μg/L for cases vs.
In univariable GLM analysis, we found no significant association between BMC and ASD, (10.9 μg/L for cases vs. Furthermore, we used two independent sample t-tests to identify factors associated with BMC in TD children. Using General Linear Models (GLM), we assessed the association between BMC and ASD status. Finally, we collected 2 mL of whole blood from each child for analysis of manganese levels. We administered a pre-tested questionnaire to assess demographic and socioeconomic information, medical history, and potential exposure to manganese. We used data from 109 ASD cases with their 1:1 age- and sex-matched TD controls to compare mean BMC in Jamaican children (2–8 years of age) with and without ASD. We also identified factors associated with BMC in typically developing (TD) Jamaican children. We investigated the possible association between blood manganese concentrations (BMC) and ASD. Several studies have hypothesized that ASD is caused through environmental exposures during crucial stages in brain development. Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that impairs social interaction and communication. Previous studies have shown neurotoxic effects in children exposed to higher levels of manganese. Manganese is an essential element for human health and development.
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